A network of independent, interconnected clinical research centers (CRCs) in sub-Saharan Africa plays a pivotal role in sustainable vaccine discovery and development
Over the past two decades, IAVI has built strong partnerships with local research institutions across five sub-Saharan African countries — Kenya, Rwanda, South Africa, Uganda, and Zambia — where the need for vaccines is most urgent. These Centers of Excellence have been instrumental in ADVANCE’s vaccine development efforts, evaluating HIV vaccine candidates and conducting epidemiological studies that provide critical data for vaccine design and guide the direction of future efficacy trials..
The partner clinical research centers (CRCs) in East and Southern Africa were pioneers in conducting Phase 1 HIV vaccine clinical trials in Africa, adhering to the highest international standards. This was made possible with the support of the United States Agency for International Development through the U.S. President’s Emergency Plan for AIDS Relief. This network is now conducting clinical trials of vaccine candidates to prevent tuberculosis and emerging infectious diseases.
At a glance
clinical research center partners
scientific researchers
years of collaboration with IAVI
HIV prevention/vaccine-related studies
Africa CRC locations
Our partner CRCs are led by highly skilled principal investigators with expertise in guiding clinical trials
The CRCs encompass a wide array of talent, from seasoned principal investigators to early- and mid-career research scientists, including laboratory technologists, clinical trial managers, scientists pursuing post-doctoral studies, medical professionals, senior scientists, and post-docs. This diversity spans both basic and translational research.
The CRCs have adopted a unique approach to community engagement, working with priority populations. This engagement ensures community support for vaccine research and development, accelerates trial enrollment, maintains high participant retention rates, and simultaneously provides at-risk populations with linkage to vital services.
Learn more about each CRC and their work
Medical Research Council/Uganda Virus Research Institute Uganda/London School of Hygiene and Tropical Medicine Uganda Research Unit on AIDS (MRC/UVRI/LSHTM)
Entebbe (HQ), Masaka, Kampala, Uganda
Learn more
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Partners in India
CRCs in Africa also collaborate with partners in India to share critical knowledge and strengthen research capacity. The partners in India include:
- YR Gaitonde Centre for AIDS Research and Education (YRG CARE)
Taramani, Chennai, India - National AIDS Research Institute (NARI)
Pune, Maharashtra, India - National Institute for Research in Tuberculosis (NIRT)
Chennai, Tamil Nadu, India
ADVANCE is made possible by the support of the American People through the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) through United States Agency for International Development (USAID). The contents of this webpage are the sole responsibility of IAVI and do not necessarily reflect the views of PEPFAR, USAID, or the United States Government.
